Efficacy of comparing furosemide and hydrochlorothiazide in chronic kidney disease at advanced stage and hypertension
10.3969/j.issn.1005-1678.2016.06.26
- VernacularTitle:呋塞米与氢氯噻嗪治疗慢性肾脏病合并高血压患者的临床疗效
- Author:
Luxi CAI
;
Hui LIU
- Publication Type:Journal Article
- Keywords:
furosemide;
hydrochlorothiazide;
chronic kidney disease;
clinical efficacy
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):94-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the antihypertensive, diuretic and natriuretic effects of furosemide and hydrochlorothiazide alone or combination in chronic kidney disease ( CKD) at advanced stage and hypertension.Methods 126 cases of chronic kidney disease at advanced stage and hypertension in our hospital were randomized divided into 3 groups (A, B and C).Each group had 42 cases.Patients of group A and B received furosemide single drug and hydrochlorothiazide single drug, respectively.Patients of group C received furosemide combined with hydrochlorothiazide.The filtration sodium excretion fraction ( FENa) , the filtration chlorine excretion fraction( FECI) , blood pressure and renal functional indexes were measured.Results There was no significant difference in FENa and FECI between pre-treatment and post-treatment in group A and B.The FENa and FECI in group C post-treatment were significant higher than pre-treatment ( P<0.05 ) .There was no significant difference in blood pressure between group A and B post-treatment.The blood pressure in group C post-treatment was significant higher than group A, group B,respectively(P<0.05).There was no significant difference in GFR between pre-treatment and post-treatment in group A and B.The GFR in group C post-treatment was significant higher than pre-treatment(P<0.05).There was no significant difference in RPF and RVR between pre-treatment and post-treatment in three groups.The GFF in three groups post-treatment were significant higher than pre-treatment( P<0.05 ) .Conclusion The antihypertensive, diuretic and natriuretic effects of single furosemide and single hydrochlorothiazide are good and have no significant difference, while the combination treatment is better.
