Effect of CAR on STZ-induced type 1 diabetic mice
10.3969/j.issn.1001-1978.2016.09.023
- VernacularTitle:香芹酚对STZ诱导的1型糖尿病小鼠糖脂代谢的影响
- Author:
Yunpei MAI
;
Shuyun ZHANG
;
Jiliang DOU
;
Guiping ZHANG
;
Jiandong LUO
;
Ning HOU
- Publication Type:Journal Article
- Keywords:
CAR;
diabetes;
C57 BL/6 mice;
STZ;
glucose and lipid metabolism;
intraperitoneal injection
- From:
Chinese Pharmacological Bulletin
2016;32(9):1306-1310
- CountryChina
- Language:Chinese
-
Abstract:
Aim Carvacrol ( CAR ) , possesses a wide variety of pharmacological properties including antioxi-dant and anti-inflammatory potential. The present stud-y is designed to investigate the effect of CAR on glu-cose and lipid metabolism in type 1 diabetic mice. Methods Diabetes was induced by intraperitoneal( i. p) injection of streptozotocin into male mice at the dose of 45 mg·kg-1 body weight( BW) . Mice were divided into three different groups containing eight to twelve in each. Age matched male C57 mice were used as nor-mal controls. Group I diabetes, Group Ⅱ and Ⅱ in-jected with CAR at 10 and 20 mg · kg-1 BW respec-tively once daily. After CAR injection 2, 4 or 6 weeks, the rats were weighted and the plasma concen-trations of glucose, total cholesterol( TC) , triglycerides (TG), Glutamic oxalacetic transaminase(AST), Ala-nine transaminase( ALT) levels were enzymatically de-termined using commercial kits. Results STZ-induced C57 BL/6 J diabetic mice showed an elevation in serum glucose, TG, ALT, AST and LDH levels. Compared to diabetic mice, administration of CAR resulted in sig-nificant decreases(P <0. 05) in plasma glucose, TG and LDH levels in a dose dependent manner, but no effect on elevated TC, ALT and AST levels. Conclu-sion These major findings provide evidence that CAR has anti diabetic property and it has the potential for development into a drug to prevent hyperglycemia, re-duce blood lipids and protect the dammaged organs.
