Evaluation of Uygur medicine in treatment of tumor by dynamic contrast-enhanced magnetic resonance
10.3969/j.issn.1002-1671.2016.07.034
- VernacularTitle:磁共振动态增强技术对维药治疗肿瘤疗效评价的研究
- Author:
Xiaoqin LI
;
Lin JIA
;
Hong WANG
;
Wenxiao JIA
- Publication Type:Journal Article
- Keywords:
dynamic contrast-enhanced magnetic resonance imaging;
colon cancer nude mice model;
Uygur drug;
effective evaluation
- From:
Journal of Practical Radiology
2016;32(7):1119-1122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate whether the functional MRI could be used to reflect the change of angiogenesis after drug treat-ment,and obtain the related semi quantitative and quantitative parameters by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).Methods The subcutaneous transplantation colorectal cancer were constructed in 20 nude mice,which were treated with Xiaoaifeimi.The transplanted tumor microvascular density,VEGF and PCNA were monitored.The therapeutic effect and MRI monitoring results were evaluated by combining DCE-MRI with the pharmacokinetic model.The semi quantitative and quantitative parameters were obtained for evaluating the effection of medicine.Half of nude mice were sacrificed to obtain the immunohistochem-ical staining.Correlation between pathological findings and parameters were analyzed.Results Compared to the control group,hu-man colon HT-29 cell proliferation rate was significantly decreased (44.87%)(P <0.05),and the apoptosis rate of HT-29 cells was increased 2.45 times (P <0.05)after Uyghur medicine treatment.The correlation between pathological examination and DCE-MRI parameters showed that Ktrans value and Kep were positively correlated with VEGF,MVD and PCNA (P <0.05).Conclusion A good relationship is showed between immunohistochemistry and DCE-MRI quantitative parameters in Uygur drug treating human colon cancer mice.
