Effects of pramipexole on serum cystatin C, antioxidant indexes and brain derived neurotrophic factor in Parkinson’s disease
10.3969/j.issn.1005-1678.2016.06.18
- VernacularTitle:普拉克索对帕金森病患者血清胱抑素C、抗氧化指标及脑源性神经生长因子水平的影响
- Author:
Binbin SONG
;
Zhihui DUAN
;
Yaming ZHANG
- Publication Type:Journal Article
- Keywords:
pramipexole;
Parkinson’s disease;
cystatin C;
antioxidant indexes;
brain derived neurotrophic factor
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(6):70-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of pramipexole on serum cystatin C, antioxidant indexes and brain derived neurotrophic factor ( BDNF) in the treatment of patients with Parkinson’s disease.Methods Retrospective a total of 96 patients with Parkinson’s disease were collected and randomly divided into experimental group and control group with 48 cases in each group.Patients in the control group were treated by levodopa,patients in the experimental group were treated on the basis of the control group with pramipexole, movement and non-movement symptoms were assessed by unified Parkinson’ s disease rating scale ( UPDRS), the serum cystatin C, antioxidant indexes and brain derived neurotrophic factor levels were measured, and the clinical efficacy and adverse reactions were compared.Results The effective rate of the control group (68.75%) was lower than the experimental group (87.50%), with statistical significance (P<0.05); compared with the control group, the movement and non-movement symptoms of the experimental group reduced after treatment, after treatment the serum CRP, serum cystatin C decreased, serum BDNF increased, after treatment the glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidate (GPX) levels increased, with statistical significance (P<0.05).Conclusion Pramipexole in the treatment of patients with Parkinson’s disease could reduce serum cystatin C, improve the levels of BDNF and antioxidant capacity, the effect is remarkable.
