Progress in role of lncRNA in cardiovascular diseases
10.3969/j.issn.1000-4718.2016.08.023
- VernacularTitle:lncRNA 在心血管疾病中作用的研究进展
- Author:
Weifeng QIN
;
Honggang ZHANG
- Publication Type:Journal Article
- Keywords:
Long noncoding RNA;
Epigenetics;
Cardiovascular diseases
- From:
Chinese Journal of Pathophysiology
2016;32(8):1471-1477
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases are closely related to proliferation , injury and apoptosis of the cells in the cardiovascular system .For instance , endothelial cells play an important role in the pathogenic process of hypertension and atherosclerosis , and smooth muscle cells and monocytes/macrophages involve in the formation of atherosclerotic plaque . Recently, it has been confirmed that long noncoding RNA (lncRNA) regulates proliferation, apoptosis, injury, autophagy and differentiation of the cells by a series of regulatory mechanisms , thus participating in the development and progression of cardiovascular diseases .This article is to review the recent research progress on the function of lncRNAs and their regu -latory roles in the cardiovascular diseases at cellular and molecular levels .
