A non-randomized controlled clinical trials：therapeutic effect of sanyrene on diabetic skin pruritus
10.3760/cma.j.issn.1672-7088.2016.19.007
- VernacularTitle:赛肤润对糖尿病皮肤瘙痒症作用效果的非随机对照临床试验
- Author:
Yan WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Skin pruritus;
Sanyrene;
Non randomized controlled clinical trial
- From:
Chinese Journal of Practical Nursing
2016;32(19):1470-1474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of sanyrene in decreasing skin itching and observe its therapeutic effect on skin pruritus in patients with diabetes. Methods According to the principle of voluntary patients, 221 cases were divided into three groups: conventional therapy plus calamine smear including 80 cases, conventional therapy plus sanyrene including 80 cases and the conventional treatment only control group including 61 cases. Results Generalized estimating equations were established. Referring to the control group, model one was established. The coefficients in sanyrene treatment and calamine control group were 2.20 and 1.29 respectively (P<0.01). The therapeutic efficacy was significantly increased with 9.03 (OR=e2.20) times in sanyrene group and 3.63 (OR=e1.29) times in calamine group compared to the blank control,indicating effect of sanyrene and calamine were better than the control group;Referring to calamine group, Model two was established,shows better efficacy of sanyrene in calamine. The coefficients in sanyrene treatment and blank control group were 0.91 and-1.29 respectively (P<0.01). The therapeutic efficacy was significantly increased 2.48 (OR = e0.91) times in sanyrene group and 0.28 (OR = e-1.29) times in blank group compared to calamine control. Conclusions Sanyrene is effective in improving in diabetic skin pruritus situation. And compared with calamine, the treatment efficacy of sanyrene is better, which suggesting that sanyrene can be used in the clinical treatment of diabetic skin pruritus.
