Lymphoma and cAMP signaling pathway
10.19401/j.cnki.1007-3639.2016.06.013
- VernacularTitle:淋巴瘤和cAMP信号通路
- Author:
Yao ZHONG
;
Qi ZHU
- Publication Type:Journal Article
- Keywords:
Lymphoma;
Cyclic adenosine monophosphate signaling pathway;
Apoptosis
- From:
China Oncology
2016;26(6):556-560
- CountryChina
- Language:Chinese
-
Abstract:
Several signaling pathways are involved in clonal proliferation of lymphoma cells and disease progression. It has been shown that cyclic adenosine monophosphate (cAMP) signaling pathway, as an important intra-cellular messenger delivery system, is related to modulation of multiple physiological processes including cell prolifer-ation, secretion, metabolism and apoptosis. Manipulating the cAMP signaling pathway can induce cell cycle arrest and apoptosis of various malignant lymphoid cells, which involves mitochondria-dependent apoptosis and cAMP-modulated protein kinases as well as changes of intracellular mediators. In-depth research and analysis of cAMP-induced apoptosis in lymphoma cells would provide potential targets and possible therapeutic means for the treatment of lymphoma.
