Analysis of hepatitis B virus genotype in regions in Guangxi with high incidence of primary liver cancer
10.3969/j.issn.1006-5725.2016.14.018
- VernacularTitle:广西肝癌高发区乙型肝炎病毒基因型分析
- Author:
Renfang SHI
;
Jizhou WU
;
Peiqi WAN
;
Jianlin WU
;
Qiuyue NING
;
Yu PANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Primary liver cancer;
Genotype;
Familial clustering
- From:
The Journal of Practical Medicine
2016;32(14):2313-2315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distribution and characteristics of hepatitis B virus (HBV) genotype in the region in Guangxi with high incidence of primary liver cancer (PLC). Methods 103 pairs of samples from the sex- and age-matched members with HBsAg-positive from PLC-clustering families (the experimental group) and carcinoma-free families (control group) were collected. Nested polymerase chain reaction (PCR) and sequencing methods were applied for the analysis of HBV genotype. Results Four HBV genotypes: B, C, B/C and D, were detected, the percentages of them in the two groups were 31.1%, 63.1%, 1.9%, 1.9% and 30.1%, 55.3%, 6.8%, 2.9%, respectively, showed no significant differences (P > 0.05). HBeAg positive rates were significantly different between genotype C and B (P < 0.05), but no significant differences were showed in such factors as gender, age, ethnic group and HBV DNA level in them (P > 0.05). Conclusions The main genotypes were types B and C besides a small number of combined genotypes B/C and D in the regions of Guangxi with a high incidence of PLC. There may be few relationships between HBV genotypes and the high incidence of PLC for familial clustering in Guangxi.
