Effect of Telbivudine on CD4 + CD25 + CD127low/- Regulatory T cell in Patients with HBeAg-positive ;Chronic Hepatitis B
10.3969/j.issn.1006-5725.2016.14.019
- VernacularTitle:替比夫定对HBeAg（＋）慢性乙型肝炎患者CD4＋CD25＋CD127low／－调节性T细胞的影响
- Author:
Huani MOU
;
Yufeng JIANG
;
Lijuan PAN
;
Tingting XIAO
- Publication Type:Journal Article
- Keywords:
Regulatory T cell;
Telbivudine;
Chronic Hepatitis B
- From:
The Journal of Practical Medicine
2016;32(14):2316-2319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of telbivudine (TBV) on the ratio of CD4+ CD25+CD127low/-regulatory T cell (Treg) of HBeAg-positive chronic hepatitis B (CHB). Methods The ratios of Treg before and after treatment for 12, 24, 36 and 48 weeks with TBV of thirty-five patients with HBeAg-positive CHB were detected. Results Ratios of Treg were (12.55 ± 1.78)%, (10.42 ± 1.04)%, (9.55 ± 0.74)%, (8.78 ± 0.67)%, (8.74 ± 0.71)%respectively before and after treatment of 12, 24, 36 and 48 weeks and all the values were lower than its former one (P < 0.05), except the 48 weeks′. Conclusions The ratio of Treg of HBeAg (+) CHB decreases after treatment with TBV.
