Advances in immune characteristics of tuberculosis patients complicated with diabetes mellitus

VernacularTitle:结核病合并糖尿病免疫特征研究进展
Author: Li LI
Publication Type:Journal Article
Keywords: Tuberculosis; Diabetes mellitus; Immune cells
From: Chinese Journal of Microbiology and Immunology 2016;36(7):549-554
CountryChina
Language:Chinese
Abstract: Diabetes mellitus( DM) rates remain highly and is increasing dramatically worldwide. Meanwhile, the incidence of tuberculosis ( TB) decreased slowly. Moreover, DM is an important risk factor for TB incidence. Therefore, TB-DM comorbidity is becoming a new challenge in the field of prevention and control of TB. TB patients complicated with DM displayed distinct pathological manifestations, severity, course of disease, treatment complexity, failure rate of anti-TB treatment, death and recurrence compared with ordinary TB patients. Infection and incidence of TB is closely related to the immune function of the host. For patients with DM or hyperglycemia, the immune function is changed, which leads to the increase of the risk of TB and also affects the condition and prognosis of the disease. The present review summarize the current advances in the study of the immunological characteristics of TB-DM comorbidity, including the changes of both innate and adaptive immune responses, aiming to provide reference for the basic research and prevention and control of TB-DM comorbidity.