Roles and mechanisms of γδT cells in bacterial infectious diseases
10.3760/cma.j.issn.0254-5101.2016.07.015
- VernacularTitle:γδT细胞在细菌感染性疾病中作用机制的研究进展
- Author:
Yashu WANG
;
Ying ZHOU
;
Keqiang WANG
- Publication Type:Journal Article
- Keywords:
γδT cell;
Pathogenic microorganism;
Research progress
- From:
Chinese Journal of Microbiology and Immunology
2016;36(7):555-560
- CountryChina
- Language:Chinese
-
Abstract:
T cells are divided into two subsets,αβΤandγδT cells, according to the T-cell recep-tor ( TCR) expressed. γδT cells are a small minority of T cells and in contrast to αβΤ cells, they do not seem to require antigen processing and major-histocompatibility-complex ( MHC ) presentation of peptide epitopes. This group of T cells is usually much less common than αβT cells, but plays an important role in anti-infection, anti-tumor and immunoregulation. This review summarizes the production, development, dis-tribution, genetic characteristics, antigen recognition characteristics, biological and immunological functions of γδT cells as well as their unique roles and mechanisms in bacterial infectious diseases.
