Preliminary study on plasma NGF expression in adriamycin induced rat heart failure model
10.3969/j.issn.1673-4130.2016.15.014
- VernacularTitle:阿霉素诱导大鼠心力衰竭模型中血浆NGF表达的初步研究
- Author:
Zheng LIANG
;
Huailong WANG
;
Xiao LI
;
Bo LI
;
Yongyi CEN
;
Zhenjun LIU
;
Shian HUANG
;
Jianying CHEN
;
Can CHEN
;
Wenjiang CHEN
- Publication Type:Journal Article
- Keywords:
heart failure;
nerve grow th factor;
adriamycin;
Wistar rats
- From:
International Journal of Laboratory Medicine
2016;37(15):2086-2088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate plasma NGF expression in adriamycin induced rat heart failure (HF) model .Methods Twenty‐five Wistar rats were randomly divided into the CHF group (n=15 ,adriamycin 4 mg/kg ,by intraperitoneal injection ,for 6 weeks) and normal control group (NC group ,n=10) ,after successful model construction ,the 6‐week observation was continuously conducted .The body mass and plasma NGF expression were detected once per 2 weeks .Results After 6 weeks later ,the body mass in the CHF group was significantly reduced ,the difference was statistically significant (P<0 .05) ,LVEDV and LVESV were sig‐nificantly increased ,while LVEF was declined obviously (P<0 .05) ,the NGF expression amount was significantly decreased com‐pared with the control group ,the differences were statistically significant (P<0 .05);the NGF expression amount was gradually re‐duced with the time extension of disease course(P<0 .05) .Conclusion Intraperitoneal injection of adriamycin can successfully in‐duce heart failure model in Wistar rats ,moreover NGF may be closely associated with HF .
