Development of Huoxiang-Zhengqi oral emulsion
10.3760/cma.j.issn.1673-4246.2016.08.018
- VernacularTitle:藿香正气口服乳剂的研制
- Author:
Jing SUN
- Publication Type:Journal Article
- Keywords:
Huoxiang-Zhengqi San;
Oral emulsion;
Pharmaceutical technology (TCD)
- From:
International Journal of Traditional Chinese Medicine
2016;38(8):737-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine a better technique for developing the Huoxiang-Zhengqi oral emulsion without ethanol. Methods The medicinal herb of prescription in Huoxiang-Zhengqi oral liquid was extracted, and the volatile oil was firstly sheared with lecithin by high speed shearing machine, and then was prepared by high-pressure homogenizer and finally was sterilized. The factors such as the amount of phospholipids, emulsifying temperature, shearing time, the times of high pressure homogenization and sterilization conditions were investigated. Results The optimization preparation process was that the volatile oil from Huoxiang-Zhengqi oral liquid was added into 50%lecithin and was dissolved in 70 ℃ water bath, then in 10 000 r/min high-speed shear. And in the phase of adding aqueous, it was sheared 5 min for the preparation of colostrum. In the high pressure homogenization machine, the first stage pressure was set at 800 bar and the second was at 80 bar, and based on the high pressure, colostrum was prepared by 8 times. Finally, the sterilization was 116 ℃, 30 min. The preparation was a brown clarified solution, which was qualified. Conclusion The preparation method was simple, stable, and easy to popularize.
