Research progress of repair enzyme MTH1 and its inhibitors
10.3969/j.issn.1001-1978.2016.08.003
- VernacularTitle:核酸氧化损伤修复酶 MTH1及其抑制剂的研究进展
- Author:
Congmin KANG
;
Xiaoli WANG
- Publication Type:Journal Article
- Keywords:
MTH1 enzyme;
purine nucleotides oxidative dam-age;
anticancer target;
MTH1 inhibitors;
Nudix hydrolases;
NUDT1
- From:
Chinese Pharmacological Bulletin
2016;32(8):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
MTH1 enzyme belongs to the family of Nudix hydro-lases, which can prevent the oxidative damage of nucleic acid by cleaning up oxidized purine nucleotides .Close relationships were found between the activity of MTH 1 and neurodegenerative dis-eases, anti-aging et al.In recent years, MTH1 has been regar-ded as a new promising target for cancer treatment , because it plays an essential role in tumor growth , survival , invasion and metastasis.The transcription and translation , structure, catalyt-ic mechanism, detection and application of MTH1 were de-scribed, as well as various MTH1 inhibitors.
