Variations of basic glomerular filtration function in experimental rabbits with partial unilateral ureteral ;obstruction
10.3969/j.issn.1006-5725.2016.14.010
- VernacularTitle:实验兔单侧输尿管部分梗阻后基础状态下肾小球滤过功能的变化特点
- Author:
Changyin WANG
;
Qisheng YANG
;
Chun GAO
;
Shun LI
;
Linglong JIANG
;
Xiaopeng TU
- Publication Type:Journal Article
- Keywords:
Ureteral obstruction;
Glomerular filtration rate;
Radionuclide imaging;
Rabbit
- From:
The Journal of Practical Medicine
2016;32(14):2283-2287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variations of glomerular function in rabbits with partial unilateral ureteral obstruction (PUUO). Methods Thirty healty adult Japanese White Rabbits were randomly divided into the control group (6 rabbits) and the obstruction group (24 rabbits). The right PUUO model was established according to Cheng′s method. According to the PUUO duration, they were eaqually divided into four subgroups:the 7 day PUUO group, the 14 d PUUO group, the 28 d PUUO group and the 56 d PUUO group. The dynamic renal imaging was performed on all rabbits, and the glomerular filtration rate (GFR) was also calculated. The correlation between the renal function and PUUO duration was analyzed , and functional variations in the healthy kidneys were observed. Results (1)To the control group, no significant difference in the renal function was found between the left and the right kidneys (t = -0.145, P = 0.894). However, to the PUUO group, the right renal GFRs were significantly lower than the left renal GFRs (P < 0.05). (2) To the right renal GFR, significant difference was observed between the 7 day PUUO group and the control group (t = 5.066, P = 0.001),but not among the 7 day PUUO group, the 14 day PUUO group, the 28 day and the 56 day PUUO group (P > 0.05), (3)No significant differences were found in the left renal GFRs among the five groups. Conclusions The function of PUUO kidneys is characterized by an obvious decrease in the early stage, followed with a steady state. The basic function of the opposite healthy kidney does not present the compensation phenomenon.
