Clinical value of transthyretin from patients with early rheumatoid arthritis

VernacularTitle:转甲状腺素蛋白在早期类风湿关节炎患者中的临床意义
Author: Lei ZHAO ; Zhihua ZHANG ; Chunqiang BAI ; Fengyun JIANG ; Zhiqiang LIANG ; Xueyan WANG ; Changlai HAO
Publication Type:Journal Article
Keywords: Early Rheumatoid Arthritis; Transthyretin; Early Diagnosis
From: The Journal of Practical Medicine 2016;32(14):2337-2339
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical value of transthyretin (TTR) from patients with early rheumatoid arthritis (ERA). Methods 58 patients with ERA , 34 patients with later RA (LRA) and 34 healthy control (HC) were included in the research. TTR was analyzed by ELISA, whose variance was analyzed. TTR density, disease activity score28 (DAS28) score and rheumatoid factor (RF) were tested, and their correlation with TTR was analyzed. Results Serum level of TTR with ERA significantly increased compared with that with LRA and HC (P < 0.05), no statistical significance with LRA group and HC. TTR level was no correlation with the number of swelling and tender joints, disease activity score 28, RF, ESR, CRP, anti-cyclic citrylinated peptide antibody and anti-keratin antibodies, hemoglobin, thrombocyte and albumin. Conclusion Serum level of TTR significantly increased with ERA patients, contributing to early diagnosis for RA.