Effects of Ulinastatin on pulmonary vascular endothelium permeability and respiratory function in ;patients with extrapulmonary acute respiratory distress syndrome
10.3969/j.issn.1006-5725.2016.14.044
- VernacularTitle:乌司他丁对肺外源ARDS患者肺毛细血管通透性及呼吸功能的影响
- Author:
Deliang WEN
;
Zhibo LI
;
Yichao WEN
;
Weijiang LIU
;
Xuming XIONG
- Publication Type:Journal Article
- Keywords:
Acute respiratory distress syndrome;
Ulinastatin;
Pulmonary Vascular Endothelium Permeability;
Extravaseular lung water
- From:
The Journal of Practical Medicine
2016;32(14):2396-2398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Ulinastatin on pulmonary vascular endothelium permeability and respiratory function in patients with extrapulmonary acute respiratory distress syndrome(ARDS exp). Methods The data of 39 patients with ARDS exp were retrospectively analyzed.According to whether treated with Ulinastatin or not, all patients were divided into Ulinastatin group(n = 21)and control group(n = 18); The level of extravascular lung water index (EVLWI), pulmonary vascular permeability index(PVPI) and respiratory function were measured before and after the treatment. Results The mortality rate of Ulinastatin group was lower than that of control group (28.6% vs 38.9%). The time of decreasing EVLWI, PVPI and improving PaO2/FiO and respiratory function in Ulinastatin group was shorter than that of control group, and the effect was superior. Conclusion Ulinastatin could reduce EVLWI and PVPI, improve pulmonary compliance and oxygenation, and reduce mortality rate in patients with extrapulmonary acute respiratory distress.
