The study of combination treatment of dexmedetomidine and ulinastatin to acute lung injury induced by is-chemia reperfusion in rats
10.3969/j.issn.1006-5725.2016.13.011
- VernacularTitle:右美托咪定联合乌司他丁治疗大鼠缺血再灌注所致急性肺损伤
- Author:
Jingjing ZENG
;
Di REN
;
Junfu LU
;
Yongwen FENG
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Ulinastatin;
Acute lung injury;
Ischemia reperfusion
- From:
The Journal of Practical Medicine
2016;32(13):2112-2115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protection effect of dexmedetomidine and ulinastatin on acute lung in-jury caused by hepatic ischemia reperfusion. Methods 50 rats were randomly divided into 5 groups: the blank group, saline group, the dexmedetomidine group, the ulinastatin group, the dexmedetomidine and ulinastatin group. Ischemia-reperfusion models were established and drugs were administrated through femoral vein. The levels of MDA, SOD and ICAM were detected. Results Compared with the blank group, the rest of the groups of PaO2, pH and SOD activity were significantly lower (P < 0.05), and BE, pathological grading, MDA, ICAM levels were significantly higher (P<0.05). PaO2, pH and SOD activity of ulinastatin group were significantly lower in the phys-iological saline group (P < 0.05), BE, pathological grading, MDA level, ICAM levels were significantly elevated in the physiological saline group (P<0.05). Conclusion Combination of dexmedetomidine and ulinastatin have protection effect on acute lung injury caused by hepatic ischemia reperfusion, its mechanism may be related to in-hibit neutrophil aggregation, improve their antioxidant capacity and inhibition of lipid peroxidation.
