Changes of thyroid hormones in patients with peripartum cardiomyopathy
10.3969/j.issn.1006-5725.2016.13.015
- VernacularTitle:围生期心肌病患者血清甲状腺激素的变化
- Author:
Fei HE
;
Jie ZHANG
;
Rong GUO
;
Ying LIANG
- Publication Type:Journal Article
- Keywords:
Peripartum cardiomyopathy;
Thyroid hormone;
Immune response
- From:
The Journal of Practical Medicine
2016;32(13):2127-2129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of thyroid hormones in patients with peripartum car-diomyopathy. Methods Seventy-two patients with peripartum cardiomyopathy were consecutively enrolled and 72 healthy women who had normal delivery were regarded as control. Among all the subjects , free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in the serum and high sensitive C-reactive protein (hs-CRP), interferon-gamma (IFN-γ) and interleukin-4 (IL-4) in the plasma were measured. Results The levels of serum FT3 and FT4 in peripartum cardiomyopathy group were significantly higher than those in control group (P < 0.05). And the level of serum TSH in peripartum cardiomyopathy group was significantly low-er than that in control group (P < 0.05). There were 24 cases with hyperthyroidism in peripartum cardiomyopa-thy group while no patient in the control group had hyperthyroidism (P < 0.05). The levels of plasma hs-CRP and IFN-γ in peripartum cardiomyopathy group were significantly higher than those in the control group (P <0.05). And the level of IL-4 in peripartum cardiomyopathy group was significantly lower than that in the control group (P < 0.05). Conclusions Serum thyroid hormones elevated in patients with peripartum cardiomyopathy and its mechanism might be related to abnormal immune reaction.
