The expression of plasma heat shock protein HSP90α and its clinical significance for lung cancer patients
10.3969/j.issn.1006-5725.2016.13.016
- VernacularTitle:肺癌患者血浆热休克蛋白90α的表达及意义
- Author:
Qian JIANG
;
Mengmeng JIN
;
Rui HUANG
;
Yin LIU
;
Ting DU
;
Yanbei ZHANG
- Publication Type:Journal Article
- Keywords:
HSP90α;
Lung cancer;
Clinicopathologic features;
Combination detection
- From:
The Journal of Practical Medicine
2016;32(13):2129-2132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression plasma heat shock protein HSP90αand its clinical signifi-cance for lung cancer patients . Methods Plasma levels of HSP90α protein of 60 patients with lung cancer and 24 healthy individuals are detected by ELISA analysis . Results The average plasma levels of HSP90αprotein [(190.338 ± 105.861) ng/mL] in patients with lung cancer were significantly higher than in healthy con-trols [(41.020 ± 19.736) ng/mL, t = 10.480, P < 0.001]. The sensitivity of HSP90α is higher than CEA, NSE, CYFRA21-1. The sensitivity of HSP90α, CEA, NSE, CYFRA21-1 and STK1 is 100%. HSP90α is correlated with STK1 and metastasis (χ2 = 4.656, P = 0.031). Conclusions This study demonstrates that the plasma level of HSP90αprotein is a useful diagnostic biomarker in lung cancer. The sensitivity is much higher when HSP90αcom-bined with CEA, NSE, CYFRA21-1 and STK1.
