Influence of preemptive analgesia with Hydromorphone Hydrochloride on postoperative cognitive function and inflammation response in the elderly patients
10.3969/j.issn.1006-5725.2016.13.024
- VernacularTitle:氢吗啡酮超前镇痛对老年患者术后认知功能及炎性细胞因子的影响
- Author:
Fengmei DUAN
;
Xuying SUN
;
Ling LI
;
Haitao WANG
;
Guiqian SHAO
- Publication Type:Journal Article
- Keywords:
Hydromorphone Hydrochloride;
Preemptive analgesia;
Postoperative cognitive dysfunc-tion (POCD);
Inflammation cytokines;
Elderly patients
- From:
The Journal of Practical Medicine
2016;32(13):2161-2163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of preemptive analgesia with Hydr- omorphone Hy-drochloride on postoperative cognitive function and inflammation cytokines in the elderly patients. Methods Ninety ASA I orⅡ elder patients were randomly divided in control group (C)and Hydromorphone Hydrochloride group(H) with 45 cases each. Hydromorphone Hydrochloride 2 mg was injected iv before induction of anesthesia in group H. Observed plasma concentrations of the CRP、 TNF-α and IL-6 at different time. Cognitive function was assessed by minimental state examination. Results Plasma the CRP、 TNF-a and IL-6 concentrations were lower and MMSE scales were higher in group H than in group C. Conclusion Preemptive analgesia with Hy-dromorphone Hydrochloride 2 mg can reduce the incidence of postoperative cognitive dysfunction in the elderly patients.
