The clinical significance of predicting the contrast-induced nephropathy after PCI by the ratio of contrast ;medium volume and glomerular filtration rate
10.3969/j.issn.1006-5725.2016.14.029
- VernacularTitle:造影剂用量与肾小球滤过率比值预测PCI术后造影剂肾病的临床意义
- Author:
Shuen TENG
;
Zheng HUANG
;
Chenglu HONG
;
Tingyan ZHU
;
Xiu YUAN
;
Yanyu CHEN
;
Shenrong LIU
;
Jinguo XIE
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
PCI;
Estimated glomerular filtration rate;
Creatinine;
Cystatin C;
CIN
- From:
The Journal of Practical Medicine
2016;32(14):2351-2354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of contrast medium (CM) volume and estimated glomerular filtration rate (CM/eGFR) in predicting contrast-induced nephropathy (CIN) after PCI. Methods A total of 307 patients after PCI were enrolled from Nanfang Hospital from May 2014 to October 2015. The patients were divided into the CIN group(n = 29) and the non-CIN group(n = 278) according to whether CIN within 72 hours after PCI. The baseline renal function was assessed by the sCr and CyC, respectively. Results Twenty-nine patients (9.4%, 29/307) developed CIN. There were significant differences in Age, CM、NTpro-BNP、IABP、 Periprocedural Hypotension、Preprocedural sCr/CyC between two groups (P < 0.05, respectively). The result of multivariate logistic regression analysis showed that Age, Cardiac function ≥Ⅲ level, IABP, use CCB, CM/eGFRMDRD, CM/eGFRCyC were independent risk predictors for CIN, respectively. Receiver Operating Characteristic (ROC) curve analysis showed that the area under the curve of CM/eGFRMDRD(AUC = 0.838) was superior to CM/eGFRCyC (AUC = 0.805) without significant difference. The sensitivity and specificity were 79.3%and 76.3%(Cut-off Point = 2.094), respectively. Conclusion Both the CM/eGFRMDRD and CM/eGFRCyC may be good methods to determine maximum CM before PCI and to predict CIN after PCI currently, without significant differences between these two predictors.
