Research progress of endothelial mesenchymal transition in cardiovascular disease
10.16571/j.cnki.1008-8199.2016.08.020
- VernacularTitle:内皮间质转分化在心血管疾病中的研究进展
- Author:
Yanhua LIU
;
Bingong LI
- Publication Type:Journal Article
- Keywords:
Endothelial-to-mesenchymal transition;
Cardiovascular disease;
Signal pathway;
Endothelial cell
- From:
Journal of Medical Postgraduates
2016;29(8):872-876
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have demonstrated that endothelial-to-mesenchymal transition ( EndMT) plays a pivotal role in the cardiovascular system, spanning cardiovascular development through to cardiovascular diseases (CVD).In this review, we describe the common signaling mechanisms that promote EndMT participating in the pathological process of CVD, and we discuss how these in-tracellular cascades participate in crosstalk to integrate cues to reverse EndMT, which potentially may provide novel therapeutic oppor-tunities for CVD.
