Etiology, clinical characteristics and prognosis of 175 infants with cholestatic jaundice
10.3969/j.issn.1006-5725.2016.13.027
- VernacularTitle:婴儿胆汁淤积性黄疸的病因、临床特点及转归分析
- Author:
Jianli ZHOU
;
Shaoming ZHOU
;
Yongwei CHENG
;
Zhongsheng ZHU
;
Huabo CAI
;
Dongling DAI
- Publication Type:Journal Article
- Keywords:
Infant;
Cholestasis;
Etiology;
Prognosis
- From:
The Journal of Practical Medicine
2016;32(13):2172-2174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To learn about the etiology , clinical characteristics and prognosis of infants with cholestasis jaundice. Methods The clinical data of 175 cholestatic patients were retrospectively analyzed , then the prognosis was followed-up with telephone. Results After analyzing the etiology , we found that among 175 patients , there were 42 with biliary atresia , of which 19 infants died , 4 recovered well after liver transplanta-tion , 8 had liver cirrhosis waiting for transplantation , 5 recovered well after Kasai Portoenterostomy and 6 lost contact. There were 2 patients with Bile duct dysplasia and 2 with congenital cholangiectasis and they had posi-tive outcomes. And 29 patients with Cytomegalovirus infection also had positive outcome. There were 16 patients with Heredity metabolic diseases , among which 13 patients were with Citrin protein deficiency; 10 had positive outcomes; 2 lost contact and 1 died. There were 3 patients with tyrosinemia , of which one had positive outcome;one lost contact and another got liver cirohosis waiting for liver transplantation. Four patients with TPN-related cholestasis all had positive outcomes. There were still 80 cases with unkown etiology , but 79 had positive out-comes and 1 case lost. The clinical characteristics showed that the infants with cholestatic jaundice often accom-panied by stool color changed , liver and spleen enlargement and so on , and often complicated with pneumonia , hypoalbuminemia and coagulation dysfunction and so on. Conclusion There are many etiologies for infants with cholestatic jaundice. Early diagnosis and early treatment would benefit the prognosis.
