Prenatal diagnosis of chromosomal abnormalities using whole genome amplification
10.3969/j.issn.1006-5725.2016.13.030
- VernacularTitle:全基因组扩增技术在产前诊断中的应用
- Author:
Xinjie CHEN
;
Yanqin SONG
;
Dunjin CHEN
;
Nan LI
;
Jiayan WANG
;
Kai LUO
;
Min CHEN
- Publication Type:Journal Article
- Keywords:
Whole genome amplification;
Array comparative genomic hybridization;
Prenatal diagnosis
- From:
The Journal of Practical Medicine
2016;32(13):2181-2183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of whole genome amplification (WGA) combined with array comparative genomic hybridization (aCGH) in prenatal diagnosis. Methods Array CGH were performed by the DNA of 18 prenatal specimens , which were amplified by WGA because of the low DNA yield. Result 3 of the 18 fetuses were 45, X0 and 9 of 15 fetuses with normal aCGH results showed healthy outcome. Conclusion It’ s feasible for prenatal diagnosis using WGA combined with aCGH which not only can shorten the reporting time but also keep the sensitivity and accuracy of detection.
