Clinical analysis of using different ovarian stimulation plans to treat patients with polycystic ovarian syndrome infertility
10.3760/cma.j.issn.1008-6706.2016.17.023
- VernacularTitle:不同促排卵方案治疗多囊卵巢综合征的疗效分析
- Author:
Lihong WU
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Clomiphene;
Menotrophin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(17):2649-2652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the curative effects of using different ovarian stimulation plans to treat polycystic ovarian syndrome (PCOS)infertility.Methods 90 cases with infertility of PCOS were chosen and randomly divided into the A,B and C three groups (30 cases in each group).The A group had clomiphene treatment, the B group had HMG treatment,while the C group had CC combined with HMG treatment.The single follicle growth rate,HCG day intrauterine membrane,follicles and reproductive hormone levels,OHSS and pregnancies were recorded and compared in the three groups.Results In the three groups,HCG,luteinizing hormone (LH)and estradiol (E2 ) all had statistically significant differences (F =15.467 and 210.223,all P <0.05),which in the C group LH and E2 were significantly higher than those in group A and group B (all P <0.05).In the three groups,testosterone (T)had no statistically significant differences (F =1.005,P >0.05).In the three groups,single follicle ovulation rate had statistically significant differences (χ2 =64.614,P >0.05),in which single follicle ovulation rate in group C >group A >group B.In the three groups,endometrial thickness and mature follicle number all had significant differences (t =28.80,6.44,4.63,all P <0.05).Of the three groups,OHSS incidence had statistically significant difference (χ2 =7.386,P >0.05)(group B >group C >group A).In the three groups,clinical pregnancy rate,average treatment period had significant differences (F/χ2 =6.667,6.667,all P <0.05),which the clinical pregnancy rate group C >group B >group A,and the average treatment period group B >group A >group C.In the three groups,multiple pregnancy rate and abortion rate had no statistically significant differences (χ2 =2.169,0.424,all P >0.05 ). Conclusion Using clomiphene combined with small dose of menotrophin to treat PCOS infertility has better stimulation ovulation effects,higher clinical pregnancy rate,shorter drug use cycle and higher safety,which could provide the basis for the treatment of patients with PCOS infertility.
