Experimental Study of Therapeutic Effect of Suhuang Zhike Capsules for Guinea Pig Model with Cough Variant Asthma
10.13359/j.cnki.gzxbtcm.2016.05.018
- VernacularTitle:苏黄止咳胶囊对咳嗽变异性哮喘豚鼠模型疗效的实验研究
- Author:
Zhongde ZHANG
;
Ming GAO
;
Jiqiang LI
;
Yuntao LIU
;
Hongtao LI
- Publication Type:Journal Article
- Keywords:
Suhuang Zhike capsules;
cough variant asthma;
cytokines;
lung/pathology;
disease models,animal;
guinea pigs
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2016;33(5):693-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Suhuang Zhike capsules(SZC) on the guinea pig model of cough variant asthma(CVA), and to explore its therapeutic mechanism. Methods Fifty guinea pigs were randomly divided into normal control group, model group, prednisone acetate tablets group, and high-and low-dose SZC groups. With reference to the related literatures, we set up the guinea pig model of CVA. The observation indexes included cough frequency, lung histopathology, the percentage of eosinophils in bronchoalveolar lavage fluid (BALF), and the serum levels of interleukin 4(IL-4), interferon gamma(IFN-γ), tumor necrosis factor alpha (TNF-α), and immunoglobumin E(IgE). Results Compared with the normal control group, the cough frequency of the model group was significantly increased(P<0.05); compared with the model group, the cough frequency of high-dose SZC group was reduced obviously(P < 0.05). Compared with the normal control group , the percentage of eosinophils in BALF of the model group was significantly increased(P < 0.05); the percentage of eosinophils of the three medication groups was lower than that of the model group (P<0.05). The pathological changes of lung tissue in the medication groups were relieved compared to the model group. Compared with the normal control group, the serum IL-4, TN F-α and IgE levels of the model group were increased significantly (P < 0 . 05); compared with the model group , the serum IL-4 and TN F-α levels of prednisone acetate tablets group were significantly decreased, and the serum TNF-α and IgE levels of high-dose SZC group were decreased significantly (P < 0.05). Conclusion SZC could reduce the serum, TNF-α and IgE levels , and relieve the cough symptom, airway inflammation and the lung tissue pathology in CVA guinea pig, so as to achieve the therapeutic effect on CVA.
