The effect of pidotimod oral liquid in treatment of bronchial asthma in children and its influence on the immune function
10.3760/cma.j.issn.1008-6706.2016.17.037
- VernacularTitle:匹多莫德口服液治疗小儿支气管哮喘的效果及其对机体免疫功能的影响
- Author:
Jinrui GAO
- Publication Type:Journal Article
- Keywords:
Asthma;
Immune system;
Pidotimod
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(17):2702-2705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of pidotimod oral liquid in the treatment of children with bronchial asthma,and its effect on immune function.Methods 260 children of bronchial asthma were selected, and they were divided into two groups by random number table method.The control group was given routine treatment, while the observation group was given pidotimod oral liquid on the basis of conventional treatment.The clinical efficacy and immune function index were compared between the two groups.Results The effective rate of the observation group was 93.85%,which was higher than 76.92% of the control group,the difference was statistically significant (χ2 =7.86,P <0.05).There was no significant difference in lung function indexes between the two groups before treatment (P >0.05).After treatment in the observation group,the FVC was (398 ±0.66)L,FEV1 was (307 ± 0.29)L,PEF was (3.58 ±0.42)L/min,and those were increased significantly compared with before treatment and the control group,the differences were statistically significant (t =7.99,853,8.27,6.88,7.12,6.73,all P <0.05). There was no statistical difference in the indexes of the two groups before treatment (P >0.05).After treatment,CD +3 was (6.974 ±3.21 )%,CD +4 was (42.95 ±4.76 )%,the ratio of CD +4 /CD +8 was (1.38 ±0.44)% of the observation group,which were significantly increased compared with pre -treatment and the control group,the CD +8 of the observation group was (24.10 ±2.96),and it was obviously lower than pre -treatment and the control group,the differences were statistically significant (t =8.43,7.55,7.54,7.51,6.74,6.55,all P <0.05).Conclusion Pidotimod oral liquid in treatment of bronchial asthma in children can significantly improve the pulmonary function and immune function of the children,the curative effect is remarkable,and the application value is high,which can carry on clinical promotion.
