Research progress of molecular mechanism on miR-29 family for regulating the formation, development and metastasis of breast cancer
10.3760/cma.j.issn.1006-9801.2016.07.017
- VernacularTitle:miR-29家族调控乳腺癌形成、发展和转移分子机制的研究进展
- Author:
Zhihua LI
;
Jianping XIONG
- Publication Type:Journal Article
- Keywords:
miR-29;
Breast neoplasms;
Gene regulation;
Molecular mechanism
- From:
Cancer Research and Clinic
2016;28(7):490-493
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs), a non-encoding small molecular RNA, is entitled to regulate gene expression after transcription, which plays a key role in the progress of tumorigenesis, growth and metastasis. MiR-29 family consists in miR-29a, miR-29b and miR-29c, all featured by the regulation of breast cancer. This review will summarize the regulation and molecular mechanism of miR-29 family in all critical stages of breast cancer, and evaluate the value of miR-29 as a new diagnostic and prognostic biomarker or therapeutic target.
