Clinical significance of CD4+CD25+Foxp3+ regulatory T cells in patients with aplastic anemia
10.3760/cma.j.issn.1009-9921.2016.07.018
- VernacularTitle:CD4+CD25+Foxp3+调节性 T 细胞在再生障碍性贫血患者中的临床意义
- Author:
Li GE
;
Xuliang SHEN
- Publication Type:Journal Article
- Keywords:
Aplastic anemia;
CD4+CD25+ regulatory T cells;
Foxp3
- From:
Journal of Leukemia & Lymphoma
2016;25(7):438-441
- CountryChina
- Language:Chinese
-
Abstract:
Acquired aplastic anemia(AA) is a disease of bone marrow failure mediated by autoimmune T cells. CD4+CD25+ regulatory T cells, which have immunosuppressive and anergic, belong to a subpopulation of T cells specialized for immune regulation and play important roles in the development of autoimmune T cells. Foxp3 plays a significant role in the development and function of regulatory T cells which have been confirmed by many investigations. In recent years, the relationship between CD4 +CD25 +Foxp3 + regulatory T cells and AA has become a hot spot of research. What’s more, its clinical significance is becoming more and more obvious in AA.
