Expression and clinical significance of clusterin in acute cerebral infarction
10.3969/j.issn.1671-8348.2016.21.019
- VernacularTitle:簇集蛋白在急性脑梗死中的表达及其临床意义
- Author:
Yan XU
;
Huihua LI
- Publication Type:Journal Article
- Keywords:
acute cerebral infarction;
clusterin;
neural function impairment;
complement C3;
Barthel index
- From:
Chongqing Medicine
2016;45(21):2942-2945
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of clusterin (CLU ) in acute cerebral infarction (ACI) .Methods A total of 154 inpatients with ACI within 48 h of the first onset in the First Affiliated Hospital of Nanchang Uni‐versity from May to December 2013 served as the ACI group and divided into subgroups according to the neural function defection degree and whether having plaque .Contemporaneous 45 individuals undergoing the healthy physical examination were selected as the control group .The serum CLU and complement C3 levels were detected .The National Institutes of Health Stroke Scale (NIH‐SS) and Barthel index scores were conducted ,the rehabilitation course and outcome until 90 d after onset were followed up ,and the comparative analysis on serum CLU level was performed .Results The serum CLU and complement C3 levels in the ACI group were significantly higher than those in the control group ,the differences were statistically significant (P<0 .01) ,moreover serum CLU was positively correlated with the complement C3 level in ACI patients(r=0 .430 ,P=0 .000) .The CLU level in the patients with plaque and severe neural function defection was higher than that in the patients without plaque and mild neural function defec‐tion ,the differences were statistically significant (P<0 .01 or P<0 .05) .Except serum CLU level had no statistical difference be‐tween the recovery group and significantly effective group (P>0 .05) ,the serum CLU level had statistically significant differences among other prognosis types of the patients groups (P<0 .01 or P<0 .05) .The lower the serum CLU level ,the rehabilitation the better .Conclusion CLU play a role by regulating the complement system after cerebral infarction occurrence ,serum CLU level is correlated with carotid arterial plaque ,neurological function defection degree and prognosis in ACI patients ,which can serve as one of biochemical indicators for evaluating the disease condition and guiding prognosis in ACI patients .
