Study on correlation between genetic polymorphisms of ADIPOR 2 with atherothrombosis cerebral infarction
10.3969/j.issn.1671-8348.2016.21.017
- VernacularTitle:ADIPOR2基因多态性与动脉粥样硬化血栓形成性脑梗死的相关性研究
- Author:
Bin YUAN
;
Lijun ZHANG
;
Qing LI
;
Chaowei WANG
- Publication Type:Journal Article
- Keywords:
atherothrombosis cerebral infarction;
adiponectin;
adiponectin receptor 2;
single nucleotide polymorphism;
inti-ma-media thickness
- From:
Chongqing Medicine
2016;45(21):2936-2938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between genetic polymorphisms of ADIPOR2 with serum APN level ,inti‐ma‐media thickness(IMT)and atherothrombosis cerebral infarction risk .Methods The case control study was adopted ,300 patients with atherothrombosis cerebral infarction in our hospital from September 2009 to September 2014 were selected as the observation group ,meanwhile contemporaneous 300 individuals undergoing the physical examination were selected as the control group .The clinical data in all the subjects were collected and performed the carotid arterial examination ,the serum APN level was detected ,the rs12342 polymorphism of ADIPOR2 gene was detected .The genetic polymorphisms of ADIPOR2 were compared between the two groups and its relationship with serum APN and IMT was analyzed .Results The probability for suffering from atherothrombosis cerebral infarction in the AA genotype was increased compared with the GG genotype ,the difference was statistically significant (OR=1 .903 ,95% CI:1 .092-2 .703 ,P=0 .011) .Compared with the control group ,the IM T values in various subgenotype groups of the observation group were elevated ,while the APN levels were decreased ,the differences were statistically significant ( P<0 .01) .Compared with the genotype GG ,the IM T values in the genotype AA and AG were increased and APN levels were de‐creased ,the differences were statistically significant (P<0 .01) .Conclusion Genetic polymorphisms of ADIPOR2 maybe a genetic locus for the pathogenesis of Chinese Han people of atherothrombosis cerebral infarction .
