Effect of 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 on IL -17,IL -23 expression of recurrent condylomata acuminata patients
10.3760/cma.j.issn.1008-6706.2016.16.034
- VernacularTitle:5-氨基酮戊酸光动力疗法联合胸腺五肽对复发性尖锐湿疣患者外周血白细胞介素-17、白细胞介素-23的影响
- Author:
Xianlu YANG
;
Haiyan WANG
;
Ruili ZHANG
;
Xuehong YU
;
Fang SU
;
Yan DONG
;
Yulu SUN
;
Xuguang LEI
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
5 -aminolevulinic acid;
Photochemotherapy;
Thymopentin 5;
Interleukin 17;
Interleukin 23
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(16):2530-2533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effect of 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 on IL -17,IL -23 expression of recurrent condylomata acuminata patients.Methods 140 patients with recurrent condylomata acuminata were randomly divided into 3 groups.53 cases in observation group were treated by 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5,42 cases in control group 1 were treated by 5 -aminolevulinic acid -photodynamic therapy,and 45 cases in control group 2 were treated by thymopen-tin -5.24 healthy subjects were served as normal controls.IL -17,IL -23 levels were determined by enzyme linked immunosorbent assay before and after the clinical therapy.Results IL -17,IL -23 levels in the patients with recur-rent condylomata acuminata were significantly lower than those in healthy subjects(t =28.10,P <0.01;t =11.10, P <0.01).There were significant differences in IL -17,IL -23 between recurrent condylomata acuminata patients and healthy persons before treatment.There was significant difference after treatment(t =61.17,P <0.01;t =28.02, P <0.01).Conclusion 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 in the treat-ment of recurrent condylomata acuminata inhibited IL -17,IL -23 expression,so as to achieve therapeutic effect.
