Efflux mechanism on carbapenems of Acinetobacter baumannii

VernacularTitle:鲍曼不动杆菌对碳青霉烯类药物的主动外排机制
Author: Lichun ZHANG ; Ping ZHUO
Publication Type:Journal Article
Keywords: Acinetobacter baumannii; Carbapenems; Efflux pump; Carbonyl cyanide m -chlorophe-nylhydrazone
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(16):2458-2460
CountryChina
Language:Chinese
Abstract: Objective To explore the drug fast mechanism on carbapenems of Acinetobacter baumannii,it is important for clinicians to choose appropriate antibiotics.Methods The influence of active efflux inhibitors carbonyl cyanide m -chlorophenylhydrazone (CCCP)on minimal inhibitory concentration (MIC)of Acinetobacter baumannii to imipenem(IMP)was measured by agar dilution method.Results At the concentration of 10mg/L,CCCP had obvi-ously effects on carbapenems MICs,the rate of resistance of imipenem decreased from 64.39% to 34.38%.In vitro CCCP enhanced the activities of imipenem.Efflux mechanism existed not only in IMP resistant strains,but also in IMP sensitive strains.But the affection of CCCP against IMP resistant strains was much stronger than that of IMP suscepti-ble strains.Conclusion Efflux pump may be one of the main mechanisms of Acinetobacter baumannii resistance to IMP,while efflux pump inhibitors may partly reduce the resistance.