The expression and significance of DNMT1 gene in oral squamous cell carcinoma
- VernacularTitle:DNMT1基因在口腔鳞状细胞癌中的表达及意义
- Author:
Ke ZHOU
;
Hong MA
;
Xiaofeng DUAN
- Publication Type:Journal Article
- Keywords:
DNA methyltransferase 1;
Oral squamous cell carcinoma;
Real-time fluorescent quantitative poly-merasechainreaction;
Immunohistochemical;
Western blotting
- From:
Journal of Practical Stomatology
2016;32(4):584-586
- CountryChina
- Language:Chinese
-
Abstract:
The expression of DNA methyltranferase 1 (DNMT1 )mRNA and protein in 20 controls of normal oral mucosa tissue and 43 cases of oral squamous cell carcinoma(OSCC)was detected by Real-Time PCR and immunohistochemical staining and Western blot respectively. DNMTl mRNA CT values in OSCC and the controls were 0.958 6 ±0.986 6 and 0.459 5 ±0.525 8 respectively(Z =-2.028,P <0.05), The positive expression of DNMT1 protein in OSCC and the controls was 87% and 25% respectively(P <0.05).DNMT1 may play a role in the development of OSCC.
