Effect of treating allergic rhinitis with intranasal corticosteroids on small airway function

VernacularTitle:治疗变应性鼻炎对小气道功能的影响
Author: Junfeng JI ; Yong ZHANG ; Manjie JIANG ; Zhiyi WANG ; Li XU ; Fei XUE ; Wei CHEN ; Qiuping WANG
Publication Type:Journal Article
Keywords: Rhinitis,Allergic,Perennial; Administration,Intranasal; Glucocorticoids; Treatment Outcome; small airway function
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2016;23(7):409-411
CountryChina
Language:Chinese
Abstract: OBJECTIVE To observe the effect of administration intranasal corticosteroids on small airway disfunction for allergic rhinitis (AR) patients. METHODS AR patients with small airway disfunction were administrated intranasal corticosteroids for twelve weeks. Before treatment, nasal VAS, RQLQ were recorded, pulmonary function test were given. After therapy, VAS, RQLQ were obtained again at the 4th, 8th and 12th week. Pulmonary function test were performed at the 4th and 12th week. RESULTS VAS, RQLQ were all improved after therapy (P <0.01). The indices of FEV1/FVC%, MMEF pred%, MEF75pred%, MEF50pred%, MEF25pred%were also improved significantly (P<0.05), especially for MMEFpred%, MEF75pred%, MEF50pred% (P<0.01). CONCLUSION Small airway lesions can be obviously improved by the intranasal corticosteroids applied for AR. It has positive significance for preventing AR from developing into asthma.