Physico-chemical properties and antimicrobial activity of silver ion dressings
10.7644/j.issn.1674-9960.2016.07.008
- VernacularTitle:含银海藻酸盐敷料理化性质及其抗菌性能的研究
- Author:
Xiaojun LI
;
Qisheng GU
;
Qingsheng WANG
;
Junjie LI
;
Qi ZHANG
- Publication Type:Journal Article
- Keywords:
biological dressings;
silver ion;
seaweed;
cytotoxicity;
antimicrobial activity;
microscopy,electron,scanning
- From:
Military Medical Sciences
2016;40(7):564-568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the physico-chemical properties , cytotoxicity and antimicrobial activity of dressings containing Ag +.Methods The morphology of this dressing was shown by the scanning electron microscope ( SEM ) .The cytotoxicity was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) method.Using the shake flask test method , the antibacterial effect of dressings was studied .Result There was no significant difference in the water vapor transmission rate between the dressings (P>0.05).Compared with the alginate calcium dressing ,silver ion dressings had a stronger swelling rate .A higher ion concentration would lead to a much larger swelling rate and slower degradation . A lower cytotoxicity was exhibited among the dressings .The silver ion dressing had stronger bacteriostasis to Gram-positive ( G+) and Gram-negative ( G-) bacteria than the alginate calcium dressing .Conclusion The experiment has proved that the silver ion dressing has stronger antibacterial activity and lower cytotoxicity , and it is more effective for wound surface healing, with a shortened treatment course .
