Predictive role of serum Hcy levels in effect of advanced lung adenocarcinoma treated with PEM
10.3969/j.issn.1673-4130.2016.14.014
- VernacularTitle:血清同型半胱氨酸对培美曲塞治疗晚期肺腺癌疗效的预测作用
- Author:
Dong HU
;
Qian WU
;
Gang CHEN
;
Lidong ZHUANG
;
Xi CHEN
;
Huaqiang ZHU
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
lung adenocarcinoma;
pemetrexed;
homocysteine;
efficacy
- From:
International Journal of Laboratory Medicine
2016;37(14):1936-1938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of serum Hcy level change in predicting the effects of pemetrexed (PEM ) chemotherapy for treating the patients with advanced lung adenocarcinoma .Methods Fifty‐seven cases of lung adenocarcinoma treated by the PEM chemotherapy were retrospectively analyzed .The fasting venous blood was collected for detecting serum Hcy level before chemotherapy and at the end of 2‐week chemotherapy .The clinical characteristics ,Hcy level before and after chemotherapy and the relation between the Hcy level with clinical effect were statistically analyzed .Results In the therapeutic effects evaluated by the im‐aging examination during treatment process ,there were no case of complete remission (CR) ,19 cases of partial remission (PR) ,22 cases of stable diseases(SD) and 16 cases of progressed diseases(PD) ,the objective response rate(ORR) was 33 .3% and disease control rate (DCR) was 71 .9% .Different clinical factors had no significant influence on the efficacy of PEM chemotherapy (P>0 .05) .In comparing the influence of Hcy level and Hcy level change on the effect of PEM chemotherapy ,the results showed that serum Hcy level before treatment had no obvious influence on curative effect ,DCR in the patients with normal serum Hcy level after treatment was significant higher than that with abnormal Hcy level ,ORR and DCR in the patients with decreased Hcy level after chemotherapy were significantly higher than those with increased Hcy level (P<0 .05) .Conclusion Monitoring the serum Hcy lev‐el change during the PEM chemotherapeutic process in the patients with advanced lung adenocarcinoma may be used in the predic‐tion of the chemotherapeutic effect .
