Function of Wnt/β-catenin signal pathway in renal tubular epithelial-mesenchymal transition regulation
10.3760/cma.j.issn.2095-428X.2016.12.023
- VernacularTitle:Wnt/β-catenin信号通路对肾小管上皮间充质转分化的调控
- Author:
Tong NIU
;
Qiran LIU
;
Ling LI
- Publication Type:Journal Article
- Keywords:
Renal interstitial fibrosis;
Epithelial-mesenchymal transition;
Wnt signal pathway;
β-catenin
- From:
Chinese Journal of Applied Clinical Pediatrics
2016;31(12):958-960
- CountryChina
- Language:Chinese
-
Abstract:
Renal interstitial fibrosis is the common pathway for a variety of chronic renal disease to final stage renal failure,the main feature of it is the large accumulation of extra cellular matrix (ECM).Myofibroblasts is the major effector cells which lead to the synthesis of ECM,an important source of myofibroblasts is epithelial-mesenchymal transition(EMT).Wnt/β-catenin signaling pathway take part in the regulation of EMT,which make it become a potential site of anti-fibrosis therapy.
