The reversal effect of abnormal savda munziq total flavonoids on leukemia cell lines
10.3760/cma.j.issn.1008-6706.2016.19.007
- VernacularTitle:维药异常黑胆质成熟剂总黄酮对白血病耐药细胞株的耐药逆转作用研究
- Author:
Nuriding HAILIQIGULI
;
Xuemei WANG
;
Mei YAN
- Publication Type:Journal Article
- Keywords:
Abnormal savda munziq total flavonoids;
Leukemia;
Multidrug resistance cell;
Reversal
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(19):2905-2910
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the reversal effect of abnormal savda munziq total flavonoids on leukemic cell lines.Methods CCK -8 method was used to detect the cytotoxicity of abnormal savda munziq total flavonoids on leukemia cells,by multivariate analysis of variance in the chemotherapy drug intervention,further calculated the reversal fold.Results CCK -8 results showed that with the increase of concentration of ASMq800(μg/mL)compared with 200(μg/mL)and 400(μg/mL),the A value of K562 /ADR cells gradually decreased,the growth curve suggested that with the increase of ASMq concentration in K562 /ADR cell,survival time was shortened,the inhibition of the cells was significantly increased.Different concentrations of ASMq on the adriamycin toxicity with increase of concen-tration of adriamycin,the inhibition of ASMq on multidrug resistance cell line was significantly higher.The reversal multiples calculated that with the increase of ASMq concentration 600 μg/mL and 900 μg/mL,the reversal index increased significantly 2.485 times and 3.651 times.Conclusion ASMq on human leukemia multidrug resistance cell line K562 /ADR could reverse the drug resistance,the reversal mechanism needs further study.
