Preparation of Metoprolol Succinate Sustained-Release Tablet and Its Content Determination

VernacularTitle:琥珀酸美托洛尔缓释片的制备与含量测定
Author: Hua ZHANG ; Rong XU
Publication Type:Journal Article
Keywords: Metoprolol sustained-release tablets,succinate; Content determination; Chromatography,high performance liquid
From: Herald of Medicine 2016;35(8):870-874
CountryChina
Language:Chinese
Abstract: Objective To establish a method of preparing metoprolol succinate sustained-release tablet and its content determination. Methods The formulation was optimized through the orthogonal design test by using release rate of the drug as an indicator.The different batches of metoprolol succinate sustained-release tablets were determined by HPLC. Results The tablets could release drug steadily and slowly as designed,which was similar to imported tablets. The linear range of metoprolol succinate was 10-70 μg?mL-1( r=0.999 8) . Conclusion The releasing rate of metoprolol succinate sustained-release tablet prepared in optimum condition can meet the requirement. This preparation technology is simple, the assay method is rapid, sensitive and reproducible.