Effect of lienal polypeptide injection combined with chemotherapy on cell immune function of patients with advanced diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2016.07.008
- VernacularTitle:脾多肽注射液联合化疗对晚期弥漫大 B 细胞淋巴瘤患者细胞免疫功能的影响及疗效
- Author:
Jie WANG
;
Liping SU
;
Jin ZHAO
;
Li MA
;
Jingrong WANG
;
Dongsheng MA
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
Lienal polypeptide injection;
Immune function;
Treatment outcome
- From:
Journal of Leukemia & Lymphoma
2016;25(7):413-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effect of lienal polypeptide injection combined with chemotherapy on patients with advanced diffuse large B-cell lymphoma. Methods Sixty patients with advanced diffuse large B-cell lymphoma were randomly divided into investigative group (30 cases) and control group (30 cases). Patients in the investigative group were administrated with lienal polypeptide injections when undergoing chemotherapy, while patients in the control group were given only chemotherapy. The clinical effect and immune function in the two groups were compared. Results After chemotherapy, the average Karnofsky score and T cell subpopulations in the investigative group were higher than those in the control group (all P<0.05). At the same time, the rate of chemotherapy related hematologictoxicity in the investigative group was significantly lower than that in the control group (P<0.05). The response rates of investigative group and control group were 80 %(24/30) and 73 %(22/30), respectively, with no statistical significance (P=0.897). Conclusion During chemotherapy, the addition of lienal polypeptide injection will improve the immune function of patients with advanced diffuse large B-cell lymphoma, stimulate bone marrow function and improve the quality of life.
