Research progress of regulatory effects of water-soluble compounds isolated form Salvia miltiorrhiza on bone metabolism
10.3969/j.issn.1001-1978.2016.07.004
- VernacularTitle:丹参水溶性成分影响骨代谢的机制研究进展
- Author:
Shuhui LI
;
Yanlong LIANG
;
Yajun YANG
;
Wenxiu LAI
;
Liao CUI
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza;
water-soluble compounds;
tanshi-nol;
salvianolic acid B;
bone metabolism;
osteoporosis
- From:
Chinese Pharmacological Bulletin
2016;32(7):902-905
- CountryChina
- Language:Chinese
-
Abstract:
Salvia miltiorrhiza is a traditional Chinese medicine for the treatment of cardiovascular diseases .Recently, increasing evidence demonstrates that the water-soluble compounds isolated from Salvia miltiorrhiza,including tanshinol and salvianolic acid B, exert a regulatory influence on bone metabolism .The under-lying mechanism of these compounds involves various pathways , such as Wnt/β-catenin, ERK, BMP, OPG/RANKL/RANK and FoxO mediated oxidative stress pathway .This paper reviews pre-vious effects and mechanism of polyphenolic acids in Salvia milt-iorrhiza , which may provide the base for the research and devel-opment of the new agents to treat osteoporosis .
