Influence of Yuejuganmaidazao Decoction on depression-like behavior and m-TOR and Akt expression in hippocampus of PPD offspring

VernacularTitle:越鞠甘麦大枣汤对抑郁子代小鼠海马Akt及 m-TOR分子表达的影响
Author: Ruyan WU ; Cai LU ; Weiei TAO ; Baomei XIA ; Wenda XUE ; Li REN ; Haoxin WU ; Gang CHEN
Publication Type:Journal Article
Keywords: PPD offspring; Yueju ganmaidazao Decoc-tion; Akt; mTOR; rapid antidepression; ketamine
From: Chinese Pharmacological Bulletin 2016;32(7):1022-1026
CountryChina
Language:Chinese
Abstract: Aim To observe the rapid antidepressant effect of Yuejuganmaidazao Decoction on postpatum de-pression offspring , and analyze its influence on the Akt and mTOR expression .Methods After postpartum de-pression model was established , the offsprings were randomly divided into the following groups: control group(CTL-F1,n =8), vehicle group (Veh,n =8) and YG group ( YG, n =8 ) .Veh group was treated with vehicle , YG group was treated with Yueju gan-maidazao Decoction(8.3 g· kg -1 ).Forced swimming test(FST) was measured 24 hours after single adminis-tration.The phosphorylation and total level of Akt and m-TOR in the hippocampus was detected by Western blot.Results The immobility time in YG group was significantly shorter than that in Veh group ( P <0.01 ) , and the expression of p-Akt and p-mTOR in the hippocampus was significantly increased ( P <0.05 ) .Conclusion Yuejuganmaidazao Decoction may rapidly alleviate depression-like behaviors of PPD offsprings through upregulation of Akt and mTOR ex-pression .