Clinical Efficacy and Impact on Fibrinogen and D-dimer of Xueshuantong Combined with Conventional Treatment in Patients at Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- VernacularTitle:血栓通联合常规治疗对慢性阻塞性肺疾病急性加重期患者的疗效及纤维蛋白原与 D-二聚体的影响
- Author:
Xucan ZHANG
;
Yongzhen WANG
- Publication Type:Journal Article
- Keywords:
Xueshuantong;
AECOPD;
Fibrinogen;
D-dimer
- From:
China Pharmacist
2016;19(7):1331-1333
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of Xueshuantong combined with the conventional treatment and the impact on fibrinogen (FIB) and D-dimer in the patients at acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Meth-ods:Totally 218 cases of AECOPD inpatients were divided into the observation group and the control group randomly .The control group received the conventional therapy , while the observation group was intravenously treated with 250 mg Xueshuantong lyophilized powder dissolved in 250 ml 10%glucose injection additionally .The treatment course was 14 days.The changes of FEV 1 , FEV1/FVC, FIB and D-dimer in the two groups after the treatment were compared , and then the clinical efficacy of the two groups was evaluated . Results:After the treatment, the levels of FEV1 , FEV1/FVC, FIB and D-dimer in the two groups were significantly improved when compared with those before the treatment , and the changes in the observation group were more significant than those in the control group (P<0.05).The total effective rate of the control group was 80.73%, and that of the observation group was 89.91% (P<0.05). Conclusion:Anticoagulant therapy using Xueshuantong on the basis of the conventional therapy can significantly reduce the amount of fibrinogen and D-dimer serum fiber in AECOPD patients , which is helpful to improving the hypercoagulable and fibrinolysis state and the lung function of AECOPD patients .
