Study on Acute Toxicity of Xiaobai Capsules in Mice
- VernacularTitle:消白胶囊的小鼠急性毒性研究
- Author:
Yangyang SONG
;
Ting LAN
;
Minghua LI
;
Xiaoye LI
;
Yanguo ZHANG
;
Muqiong LI
- Publication Type:Journal Article
- Keywords:
Xiaobai capsules;
Acute toxicity;
Median lethal dose;
The maximum dose
- From:
China Pharmacist
2016;19(7):1411-1412
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the acute toxicity of Xiaobai capsules in mice after intragastric administration .Methods: The mice were randomly divided into two groups , the treatment group and the control group .The treatment group was given Xiaobai cap-sules by gavage, 3 times daily.The acute toxicity was recorded, and the median lethal dose (LD50) and the maximum dose were deter-mined.Results:The maximum daily dose of Xiaobai capsules was 141.6 g· kg-1(equivalent to 211.3 times of the clinical dose).At the dose, the mice showed no toxicity without death in 14 days or changes in organs after the dissection .Conclusion:Xiaobai capsules have very low acute toxicity in mice after intragastric administration with high security .
