Research progress on relationship between glucose transporter 1 and tumor energy metabolism
10.3969/j.issn.1001-1978.2016.07.005
- VernacularTitle:葡萄糖转运蛋白1与肿瘤能量代谢关系的研究进展
- Author:
Suyun YU
;
Zhaoguo LIU
;
Qi JIA
;
Lichuan CHEN
;
Pingting ZHU
;
Wenxing CHEN
;
Aiyun WANG
;
Yin LU
- Publication Type:Journal Article
- Keywords:
glucose transporter-1;
tumor metabolism;
glucose;
molecular mechanisms;
specific receptor;
therapy strategies
- From:
Chinese Pharmacological Bulletin
2016;32(7):906-909
- CountryChina
- Language:Chinese
-
Abstract:
The study on tumor metabolism has been gradually be-come a hot spot in recent years .A lot of proteins involved in the regulation of tumor metabolism especially the glucose transporter protein 1(GLUT1).As a key regulatory factor mediating energy metabolism within tumor cells , GLUT1 can regulate the glucose intake and maintain the basic level of metabolism in tumor cells . More importantly, the abnormal expression of GLUT1 was asso-ciated with many kinds of tumors , of which GLUT1 was used to meet the energy requirement for the fast growth of tumor .Thus GLUT1 also played a crucial role in growth , differentiation and metastasis of tumor cells and prognosis of tumors .Meanwhile , as three-dimensional crystal structure of GLUT 1 was determined , it is possible to design the small molecular inhibitors of GLUT 1, which can realize “starve to death” tumor cells.GLUT1 can be a particularly attractive target for tumor treatment and interfer-ence.The relationship between abnormal expression of GLUT 1 protein and tumor metabolism was reviewed . Moreover , the mechanism of tumor metabolism regulated by GLUT 1 protein ex-pression and treatment of cancers were discussed , which may provide references for future research and clinical treatment .
