Effects of hydrogen sulfide on arterial vasodilatation function of renal hypertensive rats
10.3969/j.issn.1001-1978.2016.07.014
- VernacularTitle:硫化氢对肾血管性高血压大鼠动脉舒张功能的调节作用
- Author:
Guopin PAN
;
Xiaoyi ZHANG
;
Dongliang LI
;
Honggang ZHAO
;
Ruili LIU
- Publication Type:Journal Article
- Keywords:
hydrogen sulfide;
renovascular hyperten-sion;
2 K1 C;
endothelial dependent;
eNOS;
ET-1
- From:
Chinese Pharmacological Bulletin
2016;32(7):956-959
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the modulation effects of NaHS on arterial vasodilatation functions of renal hy-pertensive rats .Methods Two-kidney , one-c lip ( 2K1C ) renovascular hypertension was induced .Rats were randomly divided into four group:sham group , two-kidney one-clip model ( 2K1C ) group, 2KIC +NaSH( H2 S donor ) group, PPG group.The systolic blood pressure ( SBP ) was measured before the opera-tion and each week after the operation .The carotid ar-tery was collected for morphometric parameters ( outer radius, wall thickness, the radio of wall thickness to outer radius) and the tension of the carotid artery was observed with the isolated artery ring technique .Immu-nohistochemistry was used to determine the protein ex-pression of eNOS , ET-1 protein in carotid artery .Re-sults The blood pressure of 2K1C group and PPG group was higher than that of sham group ( P<0.05) . Compared with 2K1C group,the blood pressure and the rat arteria carotis communis of the radio of wall thick-ness to outer radius of 2K1C+NaHS group decreased significantly , while the relaxation of carotid artery to ACh in NaHS group increased .According to the immu-nohistochemistry results , eNOS expression was upregu-lated while ET-1 was downregulated in 2K1C +NaHS group as compared with 2K1C group.Conclusions Chronical administration of NaHS can decrease blood pressure in renovasocular hypertensive rats .The anti-hypertensive effect of H 2 S maybe associated with im-provement of the arterial functions .
