Quality Analysis of Radix Aucklandiae in Xianglian Preparation
- VernacularTitle:香连制剂中木香的质量分析评价
- Author:
Xiaoyong CHEN
;
Ling XU
;
Jing NIE
;
Liqun ZHANG
;
Ying CHENG
- Publication Type:Journal Article
- Keywords:
Xianglian preparation;
Radix Aucklandiae;
SPME/GC-MS;
UPLC;
Costunolide;
Dehydrocostuslactone;
Content de-termination
- From:
China Pharmacist
2016;19(7):1273-1275
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze and evaluate the quality control of Radix Aucklandiae in Xianglian preparation and develop a new quality control method for the preparation through standard testing and exploration study on 127 batches of samples .Methods:Ac-cording to the mandatory method , Radix Aucklandiae was identified by TLC .In the exploratory research , the volatile compounds in Xianglian preparation was analyzed by SPME/GC-MS, and the GC-MS fingerprints of volatile compounds in Xianglian preparation with different dosage forms were established .The contents of costunolide and dehydrocostuslactone in Xianglian preparation were determined by UPLC.Results:According to the current quality standard , all the batches of samples met the standard with the qualified rate of 100%.The composition of volatile compounds in different dosage forms was similar , while the relative contents were quite different . The contents of costunolide and dehydrocostuslactone in Xianglian preparation were different .Conclusion: The exploratory research provides reference for the further revision of drug standard and monitoring quality of the preparation .
