Efficacy and Influence on Serum IL-4 and IFN-γLevels of Xiyanping Injection in Acute Bronchitis Chil-dren
- VernacularTitle:喜炎平注射液对急性支气管炎患儿疗效及对血清白细胞介素-4、γ-干扰素水平影响观察
- Author:
Jun XIAN
;
Chunyuan HU
;
Rong HE
- Publication Type:Journal Article
- Keywords:
Xiyanping injection;
Acute bronchitis;
Interleukin-4;
Interferon-γ
- From:
China Pharmacist
2016;19(7):1299-1301
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the efficacy and influence on serum interleukin 4 (IL-4) and interferon-γ(IFN-γ) levels of Xiy-anping injection in acute bronchitis children .Methods:Totally 74 cases of acute bronchitis children were divided into the experimental group and the control group with 37 cases in each .The control group was treated with the conventional treatment , while the experimen-tal group was given Xiyanping injection additionally .Before the treatment and in 7 days after the treatment , the level changes of IL-4 and IFN-γ, improvement time of clinical symptoms , clinical curative effect and adverse reactions of the two groups were compared .Re-sults:After 7 d treatment , two groups of children with the level of serum IL-4 levels were lower than the previous treatment , the IFN-γlevels were higher than previous treatment (P<0.05); And experimental groups with serum IL-4, IFN-γlevels were significantly better than control group (P<0.05).Experimental group’s lung sound, cough and expectoration, antifebrile time significantly were shorter than the control group(P<0.05), the clinical total effective rate was significantly higher than the control group (P<0.05). The incidence of adverse drug reactions in two groups had no statistical significance (P)0.05).Conclusion:Xiyanping injection com-bined with the conventional treatment can obviously increase serum levels of IL -4 and IFN-γin acute bronchitis children , improve the clinical symptoms of patients , and shorten the disease course with few adverse reactions and promising clinical curative effect .
